Various pharmaceutical therapeutic agents are given to patients to produce its effects to the systemic circulation. Among the various dosage forms, oral route is still preferred by the patients for administration of drug. Drugs administration from an oral route is the most preferred due to several advantages over others route. It has a high rate of patient compliance as compared to other routes. Apart from the patient’s convenient, it is also available at very low price. Many groups of patients like children, elderly, mental retarded, patients having difficulties in swallowing or low intake capacity of food and water. To avoid such conditions or limitations, a novel pharmaceutical technology have been developed as Oral disintegrating tablets (ODTs). ODTs can be broadly defined as a category of oral solid dosage forms, which disintegrate in mouth or oral cavity within a minute without any presence of water at very fast or rapid speed. Apart from above mentioned limitations, it is also preferred, when the patient is travelling or have very little access to water. This review depicts the various aspects of ODTs formulation and technologies developed.