Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 1

Copper(II), Nickel(II) complexes of N-heteroaromatic hydrazone: Synthesis, Characterization and in vitro antimicrobial evaluation


The present paper describes the synthesis, spectral characterization and antimicrobial activity of the Cu(II), Ni(II) complexes prepared with N1-(2-hydroxy benzilidine)-2-phenyl isonicotino hydrazide. The complexes were characterized by elemental analysis, Infrared, NMR and Electronic spectra. From the obtained data, the proposed molecular formula of the complexes are [MX(H2L)H2O] where, M = Cu(II), Ni(II) and X = OAc or Cl. The ligand (H2L) coordinates to the central metal through ketonic oxygen, azomethine nitrogen and phenolic oxygen atoms. The antibacterial and anti fungal activity of the Cu(II), Ni(II) complexes and their parent ligand have been studied in-vitro. The complexes exhibited lethal effect on gram positive, gram negative bacteria and fungi than their parent ligand. It has also been observed that concentration of compounds played a vital role in increasing the degree of inhibition; as the concentration increases, the activity also increased.

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