Original Articles: 2014 Vol: 6 Issue: 5
Copper(II) acetate promoted facile synthesis of dihydropyrimidinone derivatives via a solvent free Biginelli multicomponent reaction
Abstract
A simple and efficient method of the 3,4-dihydropyrimidin-2(1H)-ones/thiones synthesis in good to high yields is described. It consists in a one-pot three-component Biginelli condensation using copper acetate as catalyst under solvent-free conditions.