In the present study Indolo[2,3-b]quinoxalin-1-yl-N(4-oxo-2-phenyl-1,3-thiazolidin-3-yl)acetamide derivatives were synthesized from N’-benzylidene-2-(6H-indolo [2,3-b] quinoxalin-6-yl ) acetohydrazide derivatives by conventional method and under microwave irradiation. N’-benzylidene-2-(6H-indolo [2,3-b] quinoxalin-6-yl ) acetohydrazide derivatives were synthesized from Indolo [2,3-b] quinoxalin-6-yl ) acetohydrazide. The compounds obtained were purified by column chromatography using silica gel. The chemical structures of the compounds were confirmed using IR, 1H-NMR and mass spectroscopy.