Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2014 Vol: 6 Issue: 5

Conventional and greener approach for the synthesis of some pharmacologically active derivatives of thiazolidines substituted with indolo [2,3-b]quinoxalines

Abstract

In the present study Indolo[2,3-b]quinoxalin-1-yl-N(4-oxo-2-phenyl-1,3-thiazolidin-3-yl)acetamide derivatives were synthesized from N’-benzylidene-2-(6H-indolo [2,3-b] quinoxalin-6-yl ) acetohydrazide derivatives by conventional method and under microwave irradiation. N’-benzylidene-2-(6H-indolo [2,3-b] quinoxalin-6-yl ) acetohydrazide derivatives were synthesized from Indolo [2,3-b] quinoxalin-6-yl ) acetohydrazide. The compounds obtained were purified by column chromatography using silica gel. The chemical structures of the compounds were confirmed using IR, 1H-NMR and mass spectroscopy.