This study is comparison of different antibiotics effect on the Acinetobacter baumannii by minimum inhibit bacter(MIC) method1.2. This microrganism detected from a 16 year young old patient that his right medial malleolous bone was fractured in a car accident with total and severe shin skin defect. The patient wound was infected by Acinetobacter and there was not any response to primary &secondary antimicrobial management. We assessed and recorded minimum inhibit bacter(MIC) on the many kinds of antibiotics included : Imipenem ,Ciprofloxacin ,Ceftazidim ,Ceftiriaxon,and Amikacin ; that recommended by orthopedic surgery team . Our comparative analysis reveals a highly threshold resistance to MIC in all antibiotics except Amikacin,incontrast of the past culture in new antibiogram we find sensitivity to tetracycline therefore the patient in a weekly attack period by taking 30 million crystal penicillin/12h/iv,1.5 gr amikacin/12h,/iv,200mg doxiciclin /12h/p.o treated successfully.