The aim of this study is to hasten and improve the wound healing activity. Ensuring the physicochemical compatibility,Centella asiatica extract impregnated collagen and cross-linked collagen scaffolds (CAEICDS &CAEICCDS) were formulated using different concentrations. The formulated scaffolds were subjected to physical, biochemical and histopathological examinations. Microshrinkage Temperature of the scaffolds containing 1%w/v & 1.5%w/v & 2%w/v of CAEICDS & CAEICCDS were found to be 690C, 710C , 720C & 700C, 730C,760C respectively indicating their hydrothermal stability. Wound healing studies on Male Wister Rats were performed for a period of 7 days and it was observed that the 1.5%w/v of both CAEICDS & CAEICCDS treated wistar rats possessed higher amount of Hydroxy Proline content 72.6% & 73.6% when compared to that of the existing Marketed formulation (Neu- skinTM) (60.7%) . Further better wound healing activity was observed in the 1.5%w/v CAEICDS & CAEICCDS treated rats (79.9% & 80.68%).