Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2012 Vol: 4 Issue: 7

Comparative studies on the antioxidant and scavenging activities of Garcinia kola extract and vitamin E: Modulatory effects on KBrO3?¢????? induced oxidative stress in rats


The comparative antioxidant and scavenging properti es of Garcinia kola seeds extract (GKSE) and Vitami n E (VE) were evaluated in a series of in vitro assays invol ving free radicals and reactive oxygen species. GKS E and VE exhibited marked scavenging effects (26-68%) on 1, 1 diphenyl 2-picryl hydrazyl (DPPH) radical ion in a concentration dependent manner. But VE showed a bet ter DPPH radical scavenging activity of 68% when compared with the 40% scavenging effect of GKSE. Fu rthermore, GKSE inhibited the superoxide (O 2 . ) radical more obviously than VE. At 500μg/ml, GKSE and VE scaveng ed O 2 . by 69% and 62% respectively. The scavenging of hydrogen peroxide (H 2 O 2 ) by GKSE was comparable with VE especially at higher concentrations (300- 500 μg/ml). GKSE and VE were also effective at modulating the M alondialdehyde (MDA) formation observed in the kidn eys of potassium-bromate (KBrO 3 ) treated rats. A significant increase (p<0.05) in MDA levels in kidneys treated with KBrO 3 was observed when compared with the control group. GKSE and VE elicited a 82% and 87% decrease in KBrO 3 -induced increase in MDA formation in the kidney, r espectively. The results of the present investigati on suggested that GKSE and VE are potent chemopreventi ve agents and may suppress KBrO 3 mediated renal oxidative stress in rat

rtp slot demo