In the last few years, aspirin has become a life saver against cardiovascular accident. This study was carried out to determine possible dose variations in the amount of active constituent (acetylsalicylic acid) in the various brands of aspirin drugs marketed in Maiduguri metropolitan council. In this study, ten different brands of 300mg aspirin tablet were randomly sampled from different pharmacy shops; identification test was performed on each sample to confirm the presence of the active drug (acetylsalicylic acid), and each of these samples was subjected to a rigorous quantitative analysis using HPLC and UV-spectrophotometer to determine the amount of the active drug. From the analysis, out of the ten brands of aspirin worked on, only Bond aspirin(41.7%) has less than 90% of active drug in UV-spectroscopy and Odesprin(112%) has more than 110% while Biopharma(99.77%), Kp(90%), Kunimed(100%), Maxprin(105%), Michelleaspirin(95%), Nemeprin(100%),Propon(93%) and Stop-eke(105%) passes the USP specification. In HPLC analysis, both Bond aspirin(41%) and Propon(57%) have less than 90% while Odesprin(112.6%) still has more than 110% and Biopharma(99.9%), Kp(95.5%), Kunimed(100%), Maxprin(105%), Michelle(95.5%),Nemeprin(100%), and Stop-eke aspirin(105%) passes the official specification. At the end of the study, it is convincingly seen that quantitative variation often exists among drugs of different product. However, despite the variation most drug products are within the official limit