Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2014 Vol: 6 Issue: 4

Comparative molecular docking study of rutin against GABA A type receptor and 4-aminobutyrate-aminotransferase for anti-convulsant activity

Abstract

Recently many chemical drugs are capable of causing the side effects to the humans; in order to prevent these side effects herbal based drugs is necessary for the better alternative. Epilepsy is the one of the neurological diseases caused by abnormalities in brain function nearly 50 million people were affected by this disease in entire world. Hence in this current study two different drug targets such as GABA type A receptor and 4-aminobutyrateaminotransferase were docked with the natural isolated chemical structure Rutin and also compared the efficacy of the binding in between them and found that GABA type A receptor with negative binding energy of -2.68 kcal/mol is more stable than that of 4-aminobutyrate-aminotransferase with positive binding energy of +123.47 kcal/mol. Thus rutin shows more favorable binding to GABA type A receptor, so in future instead of the chemical drugs rutin can be used as drug candidate for epilepsy treatment.