The in vitro dissolution rates of 10 and 40 mg Rosa tel Tablets (Rosuvastatin Calcium and Telmisartan) as sample from in house production of Company and Sample of Innovator were measured in various Dissolution Medias using the ro tating paddle apparatus. The Similarity factor and dissimilarity factor for both drugs was found out and release profile media as well chromatographic conditions were found out.The resul ts were encouraging indicating similar dissolution pattern of Innovator and Sample formula ted.