Poguntano (Picria fel-terrae Lour.) leaves were extracted using n-hexane and examined cytotoxicity on MCF-7 cell line. Analysis data using SPSS 19 was showed that n-hexane extract has IC50 119,906 μg/ml and the value of cytotoxicity assay on Verro cell is < 3 showed that the extract is not selective. Cytotoxicity activity and combination of n-hexane extracted with doxorubicin were evaluated using the MTT assay. The combination represents higher inhibitory effect on cell growth than the single treatment of doxorubicin on MCF-7 cell lines.