The Efficacy of Compound Sulfadiazine Suspension in the treatment of Escherichia coli and Salmonella was investigated. One hundred eighty 15-day-old chickens were randomly divided into six groups, which were blank control group, negative control group, Trisulmixos gavage group, Trisulmixos in drinking water group, Sufuning gavage group, Sufuning in drinking water group resppectively. Each group contained three repeating treatments and each treatment contains 10 chickens. Results indicated that the efficacy of both Trisulmixos gavage group and Sufuning gavage group on treating Escherichia coli and Salmonella were better than other groups. The death rates of the two groups decreased by 10 percent, and their cure rates reached 30% and 40%.