Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 4

Clinical biochemistry approaches of cardiac failure among diabetic patients

Abstract

70 - 80% of diabetic patients die of cardiovascular complications such as ischemic heart disease, atherosclerosis, hypertension, arrhythmias and congestive heart failure. All these complications seem to arise from the occurrence of oxidative stress and the development of calcium-handling abnormalities. In particular, the genetic machinery in both cardiac and vascular cells is altered in chronic diabetes. Therefore, a novel therapy needs to be designed for the treatment of diabetes-induced cardiovascular abnormalities. The present clinical study has shown that the abnormalities in cardiac functions. The insulin level was slightly elevated in diabetic patients compared to normal level, which is mainly originated from the pancreas. Glycosylated hemoglobin, triglyceride, total cholesterol and urinary glucose levels are moderately elevated in both male and female diabetic patients compared to nondiabetics. The major driving force for coronary atherosclerosis in patients with diabetes appears to reside in the lipid triad of low HDL, high triglycerides. To characterize clusters of correlated parameters in the lipid profiles of our patients. The HDL-related factor, but not the LDL-related factor was correlated to the glycemic status. These results may suggest a possible mechanism for dyslipidemia: resistance to the antilipolytic effect of insulin leads to an exaggerated flux of free fatty acids into the liver and the results are reported in this paper.