Original Articles: 2013 Vol: 5 Issue: 5
Chitosan-acryl amide grafted polyethylene glycol interpenetrating polymeric network for controlled release studies of Cefotaxime
The aim of this present study was to develop a pH sensitive interpenetrating polymeric network (IPN) hydro gels (HG) based on chitosan-acryl amide-grafted-poly ethylene glycol (CTS-AM-PEG) followed by hydrolysis that are cross-linked with glutaraldehyde (GA). Cefotaxime is an antibiotic drug was successfully loaded in these IPNHGÃ¢Â€Â™s. The HGs formed were characterized by Fourier transform infrared spectroscopy (FTIR) to confirm the grafting and cross linking response, X-ray diffraction (XRD) and differential scanning calorimetric (DSC) to monitor drug encapsulation in the polymer matrix. HGÃ¢Â€Â™s gels were evaluated for swelling index, drug content, inÃ¢Â€Â“vitro release performed in both acidic and basic conditions. The IPN matrix in this study was able to extend the release of Cefotaxime rate more than 11 hours.