Original Articles: 2013 Vol: 5 Issue: 5
Chitosan-acryl amide grafted polyethylene glycol interpenetrating polymeric network for controlled release studies of Cefotaxime
Abstract
The aim of this present study was to develop a pH sensitive interpenetrating polymeric network (IPN) hydro gels
(HG) based on chitosan-acryl amide-grafted-poly ethylene glycol (CTS-AM-PEG) followed by hydrolysis that are
cross-linked with glutaraldehyde (GA). Cefotaxime is an antibiotic drug was successfully loaded in these IPNHG’s.
The HGs formed were characterized by Fourier transform infrared spectroscopy (FTIR) to confirm the grafting and
cross linking response, X-ray diffraction (XRD) and differential scanning calorimetric (DSC) to monitor drug
encapsulation in the polymer matrix. HG’s gels were evaluated for swelling index, drug content, in–vitro release
performed in both acidic and basic conditions. The IPN matrix in this study was able to extend the release of
Cefotaxime rate more than 11 hours.