Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Case Reports: 2011 Vol: 3 Issue: 6

Case Study on Metastatic Breast cancer


In this case study, a women aged 40 was diagnosed with Metastatic breast cancer. Metastatic breast cancer is a complex multi-stage disease involving the expansion of cancerous cells from the breast to other parts of the body. It is a serious complication of breast cancer, with limited treatments avail, as metastatic disease in breast cancer is often fatal. Different molecular techniques were used to diagnosis the patient and observed, overexpression of HER2/neu Oncogene and vascular endothelial growth factor (VEGF), positive Estrogen (ER) and Progesterone receptors (PR) Expression, unusual occurrence rate of Bone micrometastases and abnormal Ras activation. Suppression of these genetically transformed cancers cell with minimal effect on normal body cells can be done with the combination of anti HER2, antiVEGF treatment, Farnesyltransferase inhibitors, together with Bisphosphonates (pamidronate or zoledronic acid ). This procedure may contribute to the proliferation of cancerous cells into a fatal disease.