Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

header
Reach Us +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2010 Vol: 2 Issue: 6

Bivalent transition metal complexes of tridentate schiff base ligands: An eco-friendly study

Abstract

A rapid, efficient, clean and environmentally benig n exclusive synthesis of Schiff bases as new ligands has been developed using condensation of 2- amino-1,3,4-thiadiazole with furfuraldehyde, thiophene-2-carboxaldehyde and pyrr ole-2- carboxaldehyde efficiently in a water suspension medium using acid catalyst with ex cellent yields under microwaves irradiation. The results are compared with conventional methods. All Schiff bases were tridentate (NNO donor) ligands that were used for complexation with Co 2+ , Ni 2+ , Cu 2+ and Zn 2+ ions. All the ecofriendly synthesized Schiff bases and their meta l complexes were characterized by analytical and spectral methods. The synthesized Schiff bases and their transition metal complexes were evaluated for their in vitro antibacterial activity against four gram-negative and two gram- positive bacterial stains by the agar-well diffusio n method. Schiff bases were found to exhibit either no or low to moderate activity but all the c omplexes exhibited varied vigorous activity against different bacteria. Schiff bases which were inactive before complexation became active and less active became more active upon coordinatio n with mentioned bivalent transition metal ions