Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

header
Reach Us +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2015 Vol: 7 Issue: 1

Biomimetic oxidation of catechol employing complexes formed in-situ with NH-pyrazole ligands and transition metallic salts

Abstract

In the present paper, our main objective is to describe the catalytic properties of the complexes formed in-situ with the NH-pyrazole ligands: L1-L7 and different metallic salts (Cu(CH3COO)2, CuSO4, Cu(NO3)2, NiCl2, Co(NO3)2, ZnCl2), which aimed to mimic the active site of catechol oxidase. In order to determine factors influencing the catecholase activity of these complexes, the effect of ligand concentration and the nature of solvent have been studied. The highest rate of catechol oxidation is given by the combination formed by one equivalent of ligand L4 and two equivalents of Cu(CH3COO)2 in THF which equal to 27,449 μmol.L-1min-1. The michaelis-Menten model is applied to obtain the kinetic parameters of the best catalyst.