Crude methanolic extract of G.mollis was found to have significant antimicrobial activity, at 250 mg/ml concentration (for both antibacterial and antifungal activity), anti-inflammatory activity, at 500 mg/kg concentration and significant decrease in arterial blood pressure and heart rate in both butanol extract at 3 mg/kg concentration and methanolic extract at 20mg/kg concentration. Bioassay guided fractionation led to the isolation of two known flavonoids compounds, luteloin(1), 7-(1-O-β-D-galacturonide)-4’-(1-O- β-glucopyranosyl)-3’4’,5,7- tetrahydroxyflavone(2), two tripenoids, 7β-hydroxy-23-ene-deoxojessic acid(3), 7β-hydroxy-23- deoxojessic acid(4) and two steroids from the aerial part of G. mollis.