The toxicity of Melamine has been catching the attention of the people since children were infected by renal disease after consumption of Melamine trained milk products. Melamine can lead to kidney stones and other urinary tract problems. Understanding the interaction between organic ligand and bio macro molecule is always helpful for us to recognize the structure. Melamine alone do not form precipitation ie stone in the kidneys since it dissolves with uric acid but when it added with Cyanuric acid needle like micro crystallites of Melamine Cyanurate which is more toxic were formed. So it must be consider the adulteration from the economic perspective. All the protein containing products are analyzed for their Nitrogen content to determine protein concentration. In this work, the interaction of Melamine with Cyanuric acid was systematically studied by Powdered XRD and Scanning Electron Microscope. The result of this work contributes to understanding the biological effect of Melamine.