Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Reviews: 2017 Vol: 9 Issue: 4

Biochemistry and Therapeutic Accesses for Enzyme Facilitated Inflammation: A Review


Inflammation is a defensive measure against the chemical or biological incursions of pathogens, damaged cells or irritants so that the homeostasis in the vascular tissues is maintained. Biochemically, the commencement of the defensive reaction pertains to the production of inflammatory mediators such as chemokines, cytokines, and eicosanoids. Subsequently, the neutrophils rush to the site of infection. Targeting the invading agents, the release of reactive oxygen species (ROS) and reactive nitrogen species (RNS) is also an ingredient of the defensive plan of the body. The acute inflammation, symptomized by pain, redness, swelling, heat and loss of function might eventually lead to the development of ailments like asthma, atherosclerosis, arthritis etc.

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