Diabetic Nephropathy is a metabolic disorder associ ated with the Diabetes mellitus. People suffering f rom diabetes are prone to nephropathy conditions. The present ai m of our study is to find out the biochemical param eters such as Glucose, Urea, Creatinine, Uric acid and Ketone bod ies. These parameters were analyzed in Sulphonyl Ur ea, Biguanide treated patients. From this study it was concluded that the above hypoglycemic agents drugs shows the maximum effect in restoring these patients to norma l condition.