Bioavailabilities enhancing agents or bioenhancers are the agents which increase the bioavailability of drugs and nutrients. Many drugs have the issue of low bioavailability. With the usage of bioenhancers it is possible to overcome the drug absorption. Bioenhancers are not effective on their own but when conjugated or co-administered with other drugs, they increase the bioavailability of the drugs. These bioenhancers can reduce the dose, dosage, drug resistance problems and make the treatment cost effective. The mechanism of bioenhancing property of these agents play vital role in pharma industries to decrease the cost of the production of the drugs. In this review, several bioavailability agents of Indian origin are discussed.