Basketball is well received by the broad masses of the people due to its high speed, high combat as well as high techniques and high difficulties features. However, just because of such sports features, sports injury especially ankle joint injury is easily generated in sports process. To better and safely bring basketball into our life, this paper made principal component analysis and Pearson correlation analysis to ankle joint injury causes in basketball process, found out the top caused for ankle joint injury is technical motion mistake. According to biomechanical and dynamic analysis, achieve ankle joint injury prevention method in scientific and rational way, so that fundamentally reduce the probability of basketball ankle joint injury and also improve basketball athlete’s antagonism ability.