The traditional teaching model has not met current teaching demands. Exploration under the multimedia environment theory structure of college autonomous learning ability and good performance measurement questionnaire emphases on presentation according with the college teaching reforms initiated by the Ministry of Education in China. The study reports on an autonomous learning model based on the multimedia. In this study, the experimental design was based on constructivist learning theory and autonomous learning theory. Then, data were collected for a comparison between an experimental and a control group. Results indicate that multimedia-based autonomy learning is superior to traditional classroom teaching. Also, it was found that encouraging greater learner autonomy produced a positive learning attitude in students. Further research opportunities are also discussed.