Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2013 Vol: 5 Issue: 7

Assessment of the In-vitro antimicrobial potential of Khaya Senegalensis ethanol leaf extract

Abstract

Khaya senegalensis is an important multipurpose tree in its natural range in sub-Saharan Africa. It is particularly valued for timber, fuel wood and medicinal purposes as well as being a popular shade and amenity tree [1]. Khaya senegalensis ethanol leaf extract was examined for antimicrobial potential against some selected clinical isolates (Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Candida albicans). Qualitative phytochemistry of the ethanol leaf extract confirmed the presence of the following active chemical constituents; saponins, flavonoids, tannins, alkaloids, glycosides and carbohydrates. Dose dependent antimicrobial activity was observed with zones of inhibition ranging from 15.00-26.00mm for S. aureus, 10.00-23.50mm for E. coli, 3.20- 16.00mm for K. pneumonia and 0.00mm (no inhibition of growth) for C. albicans. MIC for the clinical isolates is 25.00mg/ml, 12.50mg/ml, 12.50mg/ml and no effect respectively while MBC is 50.00mg/ml and 25.00mg/ml for S. aureus and E. coli respectively. The data obtained demonstrated varying activities against selected bacterial isolates and thus, confirming the use of the plant in ethnopharmacology.