Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

header
Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2016 Vol: 8 Issue: 2

Application of PCA-ANN models to spectrophotometric data for quantitative analysis of a hydrochlorothiazide and amiloride hydrochlorothiazide in pharmaceutical formulations

Abstract

A multivariate calibration-prediction techniques, principal component artificial neural networks (PCA- ANN) were applied to the spectrometric multicomponent analysis of the drug containing hydrochlorothiazide (HCT) and amiloride hydrochlorothiazide (AMH) without any separation step. The selection of variables was studied. A series of synthetic solution containing different concentrations of HCT and AMH were used to check the prediction ability of the PCA-ANN. The results obtained in this investigation strongly encourage us to apply these techniques for a routine analysis and quality control of the drug.