Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2014 Vol: 6 Issue: 6

Antioxidant activity of flavonoid compounds from the leaves of Macaranga gigantea


Three flavonoid compounds have been isolated from the leaves of Macaranga gigantea (Euphorbiaceae) namely as glyasperin A (1), broussoflavonol F (2), apigenin (3). Their structures were elucidated by spectroscopic methods including UV, IR, HRESIMS, 1D and 2D NMR analysis. Compounds 1–3 were evaluated for their radical scavenging against 2,2-diphenyl-1-picrylhydrazyl (DPPH), showing their IC50 were 125.10, 708.54, and 518.01 μM, respectively. The results indicate that as glyasperin A (1) more active than ascorbic acid (329.01 μM).

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