Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 6

Antinociceptive and edematogenic activity and chemical constituents of Talinum paniculatum Willd

Abstract

Talinum paniculatum (Portulacaceae) is popularly kn own in the region of Patos de Minas, Minas Gerais State, Brazil, as “Maria Gorda” or “Benção-de-Deus” and in traditional medicine it is used to treat inflammatory processes in general. After dried and fragmented, the plant was sequentially submitted to exhaustive percolation with hexane, ethyl acetate a nd methanol. The crude extracts were investigated f or their anti-edematogenic and anti-nociceptive activi ties through formalin-induced paw edema model. In comparison with a non-steroidal anti-inflammatory d rug (NSAID) indomethacin, the hexane and ethyl acetate extracts showed higher anti-edematogenic an d anti-nociceptive activity. In addition, through phytochemical studies, from these extracts were iso lated and identified potassium nitrate ( 1 ), the mixture of long chain hiodrocarbons hentriacontane ( 2 ), dotriacontane ( 3 ), tritriacontane ( 4 ) and pentatriacontane ( 5 ). heneicosanoic acid ( 6 ), the ester nonacosyl nonacosanoate ( 7 ), urea ( 8 ), 3-O- β -D- glucosyl- β -sitosterol ( 9 ); the mixture of β -sitosterol ( 10 ) and stigmasterol ( 11 ), and a pentaciclyc triterpene 3-O-acethyl-aleuritolic acid ( 12 ). X-Ray difratometry was used for the characteriza tion of inorganic constituent. TLC, HR-CG and spectrometric methods (IR. 1 H and 13 C NMR) were used to identify the structures of organic compounds. To th e best of our knowledge, it is the first time that compound 1 to 8 and 12 are cited as constituents of T. paniculatum.