Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 6

Antimony chloride immobilized on neutral alumina: an efficient catalyst for the solvent-free selective synthesis of 1,2-disubstituted benzimidazoles

Abstract

SbCl3–Al2O3 is proposed as a highly efficient, cost effective and reusable Lewis acid catalyst for the selective synthesis of 1,2-disubstituted benzimidazoles from o-phenylenediamine and aromatic aldehydes in an excellent yield (86-95%) using microwave (MW) irradiation under solvent-free conditions. The present methodology shows some specific advantages such as mildness, short reaction times and enhanced selectivity under solvent-free conditions.