Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

header
Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2011 Vol: 3 Issue: 3

Antimicrobial studies of synthesized azetidinone derivatives from sulfamethoxazole moiety

Abstract

A series of novel Azetidinone derivatives have been synthesized from the intermediate schiff bases. Schiff bases are prepared from sulfamethoxazole moiety by reacting the hydrazide of the parent compound with different aromatic aldehydes. Cyclocondensation of schiff’s bases with acetylchloride resulted in the formation of azetidinone derivatives. The products, characterized on the basis of satisfactory spectral data (IR, NMR, Mass spectroscopy), have shown moderate to good antimicrobial activity against some bacteria and fungi.