Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 1

Antimicrobial activity of some of chlorocobaloximes containing axial substituted pyridines

Abstract

Cobaloximes of the type [Co(dmgH)2(B)Cl] ; where, dmgH- = dimethyl glyoximate, B= 3- chlorpyridine (3-PyCl), 3-bromopyridine (3-PyBr), 4-aminopyridine (4-AP), 4-methylpyridine (4-MP), 4-N,N’-dimethyl aminopyridine (4-DMAP) and 4-cyanopyridine (4-PyCN) were prepared, characterized by the usual spectroscopic techniques and screened against microorganism for antimicrobial activity with ciprofloxacin as standard. The cobaloximes were found to be active against most of the microbes. The cobaloxime containing 4-cyanopyridine as the axial ligand showed potential inhibition; whereas, the complex [Co(dmgH)2(3-PyCl)Cl] showed the least microbial growth.