The main intent of the present study is to evaluate antibacterial activity of Curry leaves (Murraya Koeniggi) and Papaya Leaves (Carica papaya) extracts against pathogenic strains E. coli ATCC 8739 and S. typhi ATCC 14028 using Cup Plate Method. Curry and Papaya Leaves extract was used to test antimicrobial activity against the test organism E.coli ATCC8739 and S. typhi ATCC 14028. Methanol, ethanol and aqueous extracts of varying concentrations 20mcg/ml, 40mcg/ml, 60mcg/ml, and 80mcg/ml were prepared and tested against pathogenic test organisms. Gentamicin is used as standard to compare the effect of antimicrobial activity of leaf extracts in the same concentrations. The methanolic extracts of Curry and Papaya leaves have shown higher antimicrobial activity as compared to other extracts. The above studies showed that Papaya leaves and Curry leaves are having good inhibitory properties against E.coli ATCC8739 and S.typhi ATCC 14028. Therefore, solvent extracts of papaya and curry leaves could be seen as a good source for useful drugs.