The in vitro antimicrobial activity of Cassia didymobotrya and Phlogacanthus thyrsiflorus leaf extracts were studied against selected bacteria and fungi following Agar disc diffusion method. Leaves were extracted using distilled water, methanol and ethyl acetate. Three different concentrations were applied to the disc (100μg, 250μg and 500μg/disc) for each extracts. While the aqueous extracts of the selected plants leaves showed mild to moderately effective, the methanol and ethyl acetate extracts were more efficient compared to the aqueous extract. The inhibition zone diameter was seen to increase with the concentration. The results were compared with results obtained using standard antibiotics Kanamycin and Fluconazole which serve as a reference for inhibition zone diameter.