Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly employed drugs for the treatment of inflammatory conditions but the adverse effect profile is the limitations in their use. Dashamula, a combination of roots of ten plants, is a standard Ayurvedic remedy for inflammatory conditions. However, studies to evaluate its role in the inflammation process and comparison with standard NSAIDs are lacking. Albino Wistar rats of either sex were used to test the anti-inflammatory effects; carrageenin induced rat hind paw edema for acute inflammation and cotton pellet implantation for chronic inflammation. Animals (n=48) were allocated to two groups of 24 animals each. Each group was further subdivided into four sub groups, receiving either saline as control or Dashamula low dose or Dashamula high dose or Diclofenac sodium. Statistical analysis was done by using Student’s ‘t’ test. Highly significant (p<0.001) paw edema reduction in acute inflammation test and decrease in final weight of the cotton pellet in chronic inflammation test was seen in groups treated with Dashamula high dose and Diclofenac sodium and significant (p<0.05) difference in Dashamula low dose in both the models as compared to control. However, this difference was statistically insignificant between Dashamula high dose and Diclofenac sodium in both the test models. Therefore, it is concluded that the antiinflammatory activity of Dashamula is comparable to that of Diclofenac sodium and Dashamula can be a possible alternative to NSAIDs.