Ceratonia siliqua L. has been used in Moroccan traditional medicine as antidiarrheal and diuretic. The infusion of carob leaves is used as an emetic for acute poisoning. The present investigation was designed to determine the antiinflammatory potential of methanolic barks extract of Ceratonia siliqua in rodents using female Swiss mice (20-30 g) and Wistar male rats (150-250 g). The acute toxicity studies were carried out based on OECD 423 guidelines. The LD50 of Ceratonia siliqua was found to be more than 5 g/kg and did not produce mortality or changes in general behavior of the tested animals. Methanolic barks extract of Ceratonia siliqua was investigated for antiinflammatory properties by using carrageenan and experimental trauma-induced hind paw oedema in rodents at the dose of 50, 100, 200 mg/kg p.o. respectively, Indomethacin at 10 and 20 mg/kg was used as standard. From the results obtained, the methanolic barks extract of Ceratonia siliqua showed significant reduction (P ≤ 0.001) and inhibition of oedema comparable to the control and reference drug used in both models. This study showed the justification of the use of Ceratonia siliqua in the treatment of inflammatory disease conditions in Morocco.