Quercetin was studied on different model of inflammation like acute, sub-acute and chronic models. Studies were performed using different agent induced-paw edema viz., Dextran-induced paw edema, Formalin-induced paw edema and Cotton Wool Granuloma model. The dose 20 mg/kg of Quercetin were tested orally and Indomethacin at the dose of 10 mg/kg was used as standard. Thus it is revealed from the screening model that the quercetin possesses anti-inflammatory activity.