The contemporary exploration is on the Plumeria pudica leaves for Anti-helminthic activity. The part choosen for the activity is leaves of Plumeria pudica was gather from Vaageshwari College of Pharmacy, Timmapur, Karimnagar, the gathered leaves were subjected to cleaning for foreign matter and kept for shade drying to remove the excess moisture from leaves which leads to contamination then it was grounded in the mixer to get the fine powder which pass from the mesh no 40, the powder kept for soxlation with the series of solvents depending on their increasing polarity petroleum ether, ethyl acetate, chloroform and methanol as solvents. The fundamental identification tests done for all the extracts which show the presence of various secondary compounds carbohydrates, alkaloids, glycosides, terpenoids, phenols, tannins, flavonoids, steroids, proteins, and amino acids. These extracts were transmitting for their antihelminthic activity against Indian earthworm Pheretima posthuma by using various extracts. These extracts showed the dose related incapacity and expiration (death) of earth worms. From all the extracts kept for soxhlation methanol shows the better activity compared to standard drug.