Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 3

Antifungal activity studies of some quinazolinone derivatives


3-Aryl-2-methyl-quinazolin-4-ones 1 were treated with nitrofurfural diacetate 2 in presence of piperidine and drops of concentrated sulphuric acid to obtain 3-aryl-2-[(5-nitro-2- furfuryl)vinyl]quinazolin-4-ones 3 in fairly good yields. The structures of these compounds were confirmed on the basis of elemental analyses, IR, NMR and mass spectral data. These compounds were also tested for their antifungal activities.

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