Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2015 Vol: 7 Issue: 10

Antifungal activity of synthesized dithiocarbamate derivatives on Fusarium oxysporum f sp. albedinis in Algeria


The date palm is threatened both in Morocco and rec ently in Algeria by a vascular fusariose, called “B ayoud”, where the causal agent is a fungus; Fusarium oxyspo rum f sp. albedinis (Foa). A variety of dithiocarbamic ester (P1-P15) has been prepared by the condensation of l ithium dithiocarbamate salt with natural substances , itols and carbohydrates, to test their antifungal activities. The in vitro antifungal activity of these new comp ounds against this fungus was evaluated by the growth inhibitory effec t, at concentrations of 200, 100, 60, 40, 20 and 10 ppm dissolved in DMSO and placed on PDA plates at 22° C. All inhi bition observations were normalized as percentage i nhibition (pI) compared to the control plates using only DMSO . At 200 ppm most of our products inhibit the growt h of Foa with percentages of inhibition varying between 2.16 % (P14) and 64.23 % (P3). The three dithiocarbamic esters P3, P4 and P9 exhibited the highest inhibition toward mycelial gr owth of Foa (39–64%). Based on these results, large scale testing on date palm of these products is war ranted.