The alcoholic and aqueous extract of Luffa aegyptica was studied for antidiabetic activity In alloxan induced diabetic rats by oral administration of extract 100mg/kg body weight for 15 days. The effect was compared with oral dose of 4.5mg/kg Glibenclamide. The alcoholic and aqueous extract of luffa aegyptica leaves significantly decrease the blood glucose of hyperglycemic rats. Phytochemical study showed the presence of flavonoids. It is concluded that Luffa aegyptica leaf extract has significant antidiabetic activity, which lowered the fasting blood glucose level in alloxan induced diabetic rats.