Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 4

Antidiabetic activity of leaves of Spinacia oleracea Linn. in Alloxaninduced diabetic rats


To evaluate the hypoglycaemic activity of ethanolic and aqueous extract of Spinacia oleracea in normal and alloxan induced diabetic rats. The ethanolic and aqueous extract of leaves of spinacia oleraceae were orally tested at the dose of (200&400mg\kg) for hypoglycaemic effect in normal and alloxan-induced diabetic rats. In addition, changes in body weight, serum cholesterol, triglyceride assessed in the aqueous and ethanolic extract treated diabetic rats, were compared with diabetic control and normal animals histopathological observations during 12 days treatment were else evaluated. Ethanolic and aqueous extract of spinacia oleraceae produced a significant reduction in fasting blood glucose levels in the normal and significant reduction in fasting blood glucose levels in the alloxan-induced diabetic rats significant differences were observed in serum lipid profiles (Cholesterol and triglyceride) and changes in body weight by both ethanolic and aqueous treated diabetic animals concurrent histopathological studies of the pancreas of these animals showed comparable regeneration by extract which were earlier necrosed by alloxan.