Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2018 Vol: 10 Issue: 6

Anti-diabetic Activity of Aqueous Extract of Peganum Harmala Roots in Streptozotocin-induced Diabetic Rats


The Peganum harmala plant is commonly used as traditional herbal medicine in many countries including Algeria. The aim of this study was designed to evaluate the anti-diabetic properties of aqueous extract of Peganum harmala roots (AEPHR). The oral acute toxicity was evaluated. Rats were made diabetic by injection of STZ (60 mg/kg body weight, i.p) and diabetes was confirmed 72 h after induction. The AREPH was administered orally at the doses of 200 mg/kg body weight for 21 days. Screening for major classes of phytochemical was done using standard chemical tests. Oral administration of AEPHR did not exhibit toxicity at a dose of 200 mg/kg. AEPHR treated diabetic rats significantly (P <0.001) reduced elevated blood glucose. The body weight were significantly (P <0.001) increased in diabetic rats treated with AEPHR compared to diabetic control rats. Phytochemical screening showed a wealth in compounds: Tannins, saponins, alkaloids, amino acids. However flavonoids, triterpenes and sterols appeared in the form traces. It is concluded that aqueous extract of P. harmala roots are a good natural source of anti-diabetic in streptozotocin-induced diabetic rats.