India is sitting on a gold mine of well-recorded and traditionally well practiced knowledge of herbal medicine. There are very few medicinal herbs of commercial importance, which are not found in this country. India officially recognizes over 3000 plants for their medicinal value. It is generally estimated that over 6000 plants in India are in use in traditional, folk and herbal medicine. There are about 9000 firms manufacturing traditional Ayurvedic medicines in India. Major Pharmaceutical companies are currently conducting extensive research on plant materials for their potential medicinal value. Depression is a common mood disorder that impacts on all aspect of a person’s life, involving mood, thoughts, thinking, behavior, feelings etc. It is a potentially life-threatening disorder that affects hundreds of millions of people all over the world. It can occur at any age from childhood to late life. According to the World Health Organization, depression is a mental health problem affecting an estimated 121 million people worldwide. Objective of the present review is to explore some of the medicinal plant and their phytoconstituents for their anti-depressant like activity.