The weight loss technique has been used to study the corrosion inhibition of mild steel in 0.1N, 0.01N and 0.001N (HCl, HNO3 and H2SO4) acidic medium by the antibiotic drug’s. Thus inhibition efficiency was obtained of various antibiotic drugs. The phenomenon of chemical adsorption form thin film on the surface of the material that stops access of the corrosive substance to the metal which increases in its inhibition efficiency