Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 6

Antibacterial efficacy and Phytochemical analysis of organic solvent extracts of Calotropis gigantea


The leaves extract of Calotropis gigantea were screened for its antibacterial and phytochemical activities. The solvents used for the leaves extraction were n-Hexane, Ethanol, Methanol, Chloroform, Water and Ethyl acetate. The extract was tested against Bacillus cereus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Salmonella typhi and Micrococcus luteus for its antibacterial activity. Ethyl Acetate leaves extract exhibited maximum zone of inhibition. Ethyl Acetate leaves extract was found to be most effective with MIC value also ranging from 0.25 to 1.0 mg/ml. Aqueous leaves extract showed weak antibacterial activity. A small portion of the dry extract was used for the phytochemical tests for compounds which include alkaloids, cardic glycoside, anthraquinone, tannins, saponins, flavnoid, steriods, terpeniods, reducing sugars and resins in accordance with the methods.