Two Philippine endemic Ficus species, Ficus casiguranensis and Ficus camarinensis (Moraceae) were tested for their pharmacological activities. Acute oral toxicity test of the crude extracts using the OECD guidelines 425 showed their non-toxic characteristics up to 2000 mg/kg of body weight. Antimicrobial test using disc-diffusion assay showed that the crude and semi-crude extracts of both plants were active against the Gram-positive bacteria. The chloroform extract of F. casiguranensis was found to be active in all the organisms tested. A modified WHO protocol for larvicidal bioassay was used to determine the larvicidal activity of the crude and semi-crude extracts of both plants. The n-butanol extract of F. camarinensis had shown the lowest Lethal Concentration (LC50) and LC90 at 268.5 ppm and 281.4 ppm for 24 hours and 265.2 ppm and 278.6 ppm for 48 hours, respectively.