Strychnos nux vomica is a poisonous tree which is used to cure diseases like anemia, lumbago, asthma, bronchitis, paralysis, muscle weakness and appetite loss. The present study investigated the anti-angiogenic activity of Strychnos nux vomica leaf extract on a chick chorioallantoic membrane assay model(CAM Assay). Angiogenesis forms an important step in the development of cancer. If this process could be intervened there will be an indirect way to stop the cancer. Chorio allantoic membrane of chick embryos were used to evaluate the antiangiogenic activity of the methanolic extract of the Strychnos nux vomica leaves with different concentrations (5μg/ml,10μg/ml and 20μg/ml).The regression/absence of the blood vessels in the localised area in the CAM disk by visual observation was documented. In conclusion, results revealed the dose dependent antiangiogenic property of the Strychnos nux vomica leaf extract, by which it appears to be possessing anticancer phytochemicals which can be isolated and used as a anticancer drug.