In this paper, different formulation types of microparticulate systems such as beads, microbeads, microspheres and microsponges using to special attention chitosan, alginate and eudragit RS 100 are reviewed. Chitosan and alginates are natural, anionic or cationic, biocompatible, biodegredable and non-toxic polymers. They have excellent potential for pharmaceutical and biopharmaceutical applications. Eudragit RS is an acrylic copolymer and it has well-established mucoadhesive characteristics. It is still being used as a sustained release coating materials in pharmaceutical field. Various techniques used for preparing chitosan, alginate and eudragit RS microparticles have also been reviewed. This review also includes non steoridal antiinflammatory drug (NSAID) microparticle formulations which have been prepared with these polymers to minimize side effects and to obtain controlled release drug delivery systems. Moreover, literatures and patents underline a widespread use of alginate, chitosan and eudragit RS are covered in this paper.