In this paper, different formulation types of micro particulate systems such as beads, microbeads, microspheres and microsponges using to special atte ntion chitosan, alginate and eudragit RS 100 are reviewed. Chitosan and alginates are natural, anionic or cationic, biocompatible, biodegredable and non-toxic polymers. They have excellent potential for pharmaceutical an d biopharmaceutical applications. Eudragit RS is an a crylic copolymer and it has well-established mucoadhesive characteristics. It is still being use d as a sustained release coating materials in pharmaceutical field. Various techniques used for p reparing chitosan, alginate and eudragit RS microparticles have also been reviewed. This review also includes non steoridal anti- inflammatory drug (NSAID) microparticle formulation s which have been prepared with these polymers to minimize side effects and to obtain con trolled release drug delivery systems. Moreover, literatures and patents underline a wides pread use of alginate, chitosan and eudragit RS are covered in this paper