Design for Six Sigma (DFSS) is a popular design concept and systematic methodology aiming at quality and reliability improvements based on customer requirements and market competitiveness; however, now, there is no unified model and tools for DFSS activities and the conventional DFSS easily overlook the complexity in production processes. In this article, an innovative DFSS for multivariate production process is divided into four main phases, namely, identify, design, optimize and verify (IDOV), with methodologies and tools analyzed thoroughly